βCDP（β-シクロデキストリンポリマー）最新研究3選（Frontier）— 医療・環境・製剤への広がり

by 原 | Posted on
[“βCDP”, “β-cyclodextrin”, “cyclodextrin polymer”, “host–guest”, “adsorption”, “drug delivery”, “materials”]

1分でわかる：βCDPは「分子をつかまえる力」を材料にしたもの

β-シクロデキストリン（βCD）は、ドーナツ状の“空洞”をもつ分子で、条件が合うと別の分子を取り込み（包接）ます。
βCDを多数つないだ βCDポリマー（βCDP） は、空洞が増えることで、
– 不要な分子を捕まえる（吸着・除去）
– 必要な分子を保持し、放出を調整する（ドラッグデリバリー/製剤）
– 分子の動き方を制御する（複合材料・膜・ゲル）
といった応用が期待されます。

このページでは、添付の βCDP_Frontier.txt に含まれる論文から、βCDP/βCD材料の“今どきの使い方”が見える3本を選び、一般の方向けにやさしく解説します。

今回の3本で見える「βCDPの使われ方」

  • 医療（神経疾患モデル）：コレステロールの“たまり”にアプローチ
  • 環境・センシング：色素分子をモデルに、包接×吸着×分光で機能を設計
  • 製剤（口腔内フィルム）：難溶性薬をβCD複合体として使いこなす

論文ハイライト（3本）

Paper 1: A water-soluble β-cyclodextrin polymer reduces cholesterol accumulation and autophagy dysfunction in vitro and in Niemann-Pick type C disease model mice

  • 掲載誌：Carbohydrate Polymers（2026）
  • 要点（かんたん解説）：
  • 水溶性のβ-シクロデキストリンポリマー（βCDP）を用い、細胞・動物モデルでコレステロール蓄積の低減を評価。
  • 血中での滞留（循環）時間が長いこと、オートファジー関連の異常が改善する方向の結果を報告。
  • 神経変性疾患関連の“分子を捕まえる”材料としての可能性を示す。
  • 原文アブストラクト（要約）：Niemann-Pick disease type C (NPC) and Alzheimer’s disease (AD) are characterised by cognitive dysfunction and neurological impairment. In both diseases, the abnormal accumulation and disruption of cholesterol homeostasis in the brain may contribute to the…
  • DOI：https://doi.org/10.1016/j.carbpol.2025.124676

Paper 2: Supramolecular interactions and adsorption behavior of β-cyclodextrin-functionalized polyacrylates toward Rhodamine B

  • 掲載誌：Surfaces And Interfaces（2026）
  • 要点（かんたん解説）：
  • βCD誘導体をポリアクリレートに導入し、色素分子（ローダミンB）などをモデルに包接・吸着挙動を解析。
  • UV-Vis/蛍光/誘起円二色性（ICD）/EPRなど複数手法でホスト–ゲスト相互作用を示す。
  • 吸着容量や速度論（擬一次モデル、ラングミュア等温線）などを整理し、環境・センシング材料への応用可能性を示す。
  • 原文アブストラクト（要約）：This study develops novel polymers by functionalizing sodium polyacrylate (NaPA) with beta-cyclodextrin (beta-CD) derivatives. Successful grafting was confirmed by FTIR and H-1 NMR spectroscopy, while mu DSC analysis revealed that CD units hinder polymer…
  • DOI：https://doi.org/10.1016/j.surfin.2025.108334

Paper 3: Exploring new buccal films based on hydroxyethyl cellulose and Linecaps® combination for the pediatric delivery of hydrophobic molecules

  • 掲載誌：Carbohydrate Polymers（2026）
  • 要点（かんたん解説）：
  • βCD誘導体をポリアクリレートに導入し、色素分子（ローダミンB）などをモデルに包接・吸着挙動を解析。
  • UV-Vis/蛍光/誘起円二色性（ICD）/EPRなど複数手法でホスト–ゲスト相互作用を示す。
  • 吸着容量や速度論（擬一次モデル、ラングミュア等温線）などを整理し、環境・センシング材料への応用可能性を示す。
  • 原文アブストラクト（要約）：Polysaccharides and starch derivatives can play a role in the development of buccal films and patches. Buccal films are a valid approach to the transmucosal administration of drugs. These drug-delivery systems are adaptable to the mucosal surface, while being…
  • DOI：https://doi.org/10.1016/j.carbpol.2025.124499

3本からの共通メッセージ（研究・教育の観点）

  • βCDPの価値は「分子レベルの相互作用（包接・結合）」を「材料として使える形（ポリマー、フィルム、機能化高分子）」へ変換できる点にあります。
  • “何を捕まえるか（ターゲット分子）”と、“どう使うか（医療/環境/製剤）”で、設計すべき材料パラメータが変わるのがポイントです。
  • 水溶性、循環時間、細胞毒性（医療）
  • 吸着容量、速度論、分光応答（環境・センシング）
  • 味・放出・粘膜付着・機械強度（製剤）

用語ミニ解説

  • 包接（ホスト–ゲスト）：βCD（ホスト）の空洞にゲスト分子が入る現象。
  • 誘起円二色性（ICD）：分子が空洞に入り“向き”が揃うと、円偏光に対する吸収差が現れることがある指標。
  • EPR（電子スピン共鳴）：ラジカル（スピンプローブ）の運動性変化から、結合や拘束を読み取る手法。
  • ラングミュア等温線：吸着が単分子層で進むような場合の代表的な吸着モデル。

参考文献（添付ファイル収録論文から）

  1. Kubohira, Y, Okano, N, Taharabaru, T, Ishimatsu, A, Era, T, Yanagihara, K, Ishikura, K, Nakagawa, Y, Higashi, T, Motoyama, K. A water-soluble β-cyclodextrin polymer reduces cholesterol accumulation and autophagy dysfunction in vitro and in Niemann-Pick type C disease model mice. Carbohydrate Polymers (2026) 374, Article 124676. DOI: https://doi.org/10.1016/j.carbpol.2025.124676.
  2. Leonties, AR, Baran, A, Ionita, G, Precupas, A, Sanda, G, Ciutu, ML, Bucur, AG, Jerca, VV, Aricov, L. Supramolecular interactions and adsorption behavior of β-cyclodextrin-functionalized polyacrylates toward Rhodamine B. Surfaces And Interfaces (2026) 80, Article 108334. DOI: https://doi.org/10.1016/j.surfin.2025.108334.
  3. Magnano, GC, Scomparin, A, Argenziano, M, Spagnolo, R, Muntoni, E, Voinovich, D, Hasa, D, Bianchi, V, De Munari, I, Cavalli, R. Exploring new buccal films based on hydroxyethyl cellulose and Linecaps® combination for the pediatric delivery of hydrophobic molecules. Carbohydrate Polymers (2026) 371, Article 124499. DOI: https://doi.org/10.1016/j.carbpol.2025.124499.

English (for website)

In one minute: βCDP turns “molecule-capturing” into a practical material

β-Cyclodextrin (βCD) is a donut-shaped host molecule with a cavity that can include guest molecules under suitable conditions.
A βCD polymer (βCDP) connects many βCD units, increasing available cavities and enabling:
– capture/removal of target molecules (adsorption)
– retention and controlled release (drug delivery/formulation)
– control of transport and interfaces in composites/films

Below are three recent papers selected from the attached file βCDP_Frontier.txt, summarized in plain language.

What these 3 papers collectively show

  • Biomedical direction: βCDP for cholesterol-related dysfunction in disease models
  • Environmental/sensing direction: βCD-functionalized polymers controlling binding/adsorption and optical response
  • Formulation direction: βCD complexes enabling practical dosage forms (e.g., buccal films)

Highlights (3 papers)

Paper 1: A water-soluble β-cyclodextrin polymer reduces cholesterol accumulation and autophagy dysfunction in vitro and in Niemann-Pick type C disease model mice

  • Journal: Carbohydrate Polymers (2026)
  • Key takeaways (plain language):
  • Evaluates a water-soluble β-cyclodextrin polymer (βCDP) in cell and mouse models with cholesterol accumulation.
  • Reports longer circulation time and improvements linked to cholesterol reduction and autophagy-related dysfunction.
  • Positions βCDP as a potential therapeutic “molecule-capturing” material in neurodegeneration-related contexts.
  • Abstract (condensed): Niemann-Pick disease type C (NPC) and Alzheimer’s disease (AD) are characterised by cognitive dysfunction and neurological impairment. In both diseases, the abnormal accumulation and disruption of cholesterol homeostasis in the brain may contribute to the…
  • DOI: https://doi.org/10.1016/j.carbpol.2025.124676

Paper 2: Supramolecular interactions and adsorption behavior of β-cyclodextrin-functionalized polyacrylates toward Rhodamine B

  • Journal: Surfaces And Interfaces (2026)
  • Key takeaways (plain language):
  • Grafts βCD derivatives onto polyacrylates and probes host–guest binding/adsorption using Rhodamine B and spin probes.
  • Supports inclusion/interaction via UV–Vis, fluorescence, induced circular dichroism (ICD), and EPR.
  • Quantifies adsorption capacity and kinetics (pseudo-first-order, Langmuir), highlighting potential for environmental and smart sensing materials.
  • Abstract (condensed): This study develops novel polymers by functionalizing sodium polyacrylate (NaPA) with beta-cyclodextrin (beta-CD) derivatives. Successful grafting was confirmed by FTIR and H-1 NMR spectroscopy, while mu DSC analysis revealed that CD units hinder polymer…
  • DOI: https://doi.org/10.1016/j.surfin.2025.108334

Paper 3: Exploring new buccal films based on hydroxyethyl cellulose and Linecaps® combination for the pediatric delivery of hydrophobic molecules

  • Journal: Carbohydrate Polymers (2026)
  • Key takeaways (plain language):
  • Grafts βCD derivatives onto polyacrylates and probes host–guest binding/adsorption using Rhodamine B and spin probes.
  • Supports inclusion/interaction via UV–Vis, fluorescence, induced circular dichroism (ICD), and EPR.
  • Quantifies adsorption capacity and kinetics (pseudo-first-order, Langmuir), highlighting potential for environmental and smart sensing materials.
  • Abstract (condensed): Polysaccharides and starch derivatives can play a role in the development of buccal films and patches. Buccal films are a valid approach to the transmucosal administration of drugs. These drug-delivery systems are adaptable to the mucosal surface, while being…
  • DOI: https://doi.org/10.1016/j.carbpol.2025.124499

Common takeaway

βCDP research links molecular recognition (host–guest inclusion) to macroscopic functions (therapy-oriented materials, adsorption/sensing, and formulation performance).
Design requirements differ by application—solubility and circulation (biomed), adsorption capacity/kinetics and spectroscopic readouts (environment/sensing), or release/mucoadhesion/mechanics (formulation).

References (from the attached file)

  1. Kubohira, Y, Okano, N, Taharabaru, T, Ishimatsu, A, Era, T, Yanagihara, K, Ishikura, K, Nakagawa, Y, Higashi, T, Motoyama, K. A water-soluble β-cyclodextrin polymer reduces cholesterol accumulation and autophagy dysfunction in vitro and in Niemann-Pick type C disease model mice. Carbohydrate Polymers (2026) 374, Article 124676. DOI: https://doi.org/10.1016/j.carbpol.2025.124676.
  2. Leonties, AR, Baran, A, Ionita, G, Precupas, A, Sanda, G, Ciutu, ML, Bucur, AG, Jerca, VV, Aricov, L. Supramolecular interactions and adsorption behavior of β-cyclodextrin-functionalized polyacrylates toward Rhodamine B. Surfaces And Interfaces (2026) 80, Article 108334. DOI: https://doi.org/10.1016/j.surfin.2025.108334.
  3. Magnano, GC, Scomparin, A, Argenziano, M, Spagnolo, R, Muntoni, E, Voinovich, D, Hasa, D, Bianchi, V, De Munari, I, Cavalli, R. Exploring new buccal films based on hydroxyethyl cellulose and Linecaps® combination for the pediatric delivery of hydrophobic molecules. Carbohydrate Polymers (2026) 371, Article 124499. DOI: https://doi.org/10.1016/j.carbpol.2025.124499.

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