created: 2026-01-31
論文1：Dual-MIP PEDOT/nCuNi-nanocatalyst sensor for simultaneous detection of dopamine and vanillylmandellate
- 著者：Demkiv, O; Stasyuk, N; Holdynski, M; Nogala, W; Gonchar, M
- 掲載誌：MICROCHEMICAL JOURNAL（2026）
- キーワード：Molecularly imprinted polymer; Dual-template sensor; CuNi nanoparticles; Dopamine; Vanillylmandelic acid; Electrochemical detection
- DOI：10.1016/j.microc.2025.116746
何の研究？（ひとことで）
βCDを“分子の受け皿”として組み込んだ分子鋳型（MIP）センサーで、尿中の2種類バイオマーカーを同時に高感度検出した研究
ポイント（やさしく）
- βCDの包接（ホスト–ゲスト）相互作用により、目的分子を選択的に取り込みやすい認識層を作る。
- CuNiナノ粒子で電気化学シグナルを増強し、低濃度でも検出できるようにする。
- 実試料（尿）でHPLCと整合する結果を示し、ポイントオブケア診断への可能性を示した。
応用イメージ（どこに役立つ？）
- 医療現場での迅速検査（ポイントオブケア）
- 複数成分を一度に測る小型分析デバイス
- βCD系材料を使った高選択認識層の設計
論文2：Characterization of Eudragit Nanoparticle-Tailored β-Cyclodextrin/Thiolated Sodium Alginate/Polyethyleneglycol Polymer Hybrid as a Potential Bone Tissue Engineering Scaffold
- 著者：Rahaman, J; Mukherjee, D
- 掲載誌：AAPS PHARMSCITECH（2026）
- キーワード：bone tissue regeneration; eudragit nanoparticle; freeze-thaw; polymer hybrid scaffold; thiolated sodium alginate
- DOI：10.1208/s12249-025-03314-1
何の研究？（ひとことで）
βCDとアルギン酸・PEGなどを組み合わせたハイブリッドハイドロゲルに、ナノ粒子を導入して骨再生向け足場材を設計した研究
ポイント（やさしく）
- βCDの構造（疎水内孔＋親水外側）を活かし、材料の相互作用や薬物担持性を高める発想。
- 凍結融解（freeze–thaw）で化学架橋剤を使わずにゲル化し、細孔構造や水分保持性を調整。
- 細胞毒性が低いこと、骨形成関連タンパク質への結合が示唆されることから、骨組織工学への適性を議論。
応用イメージ（どこに役立つ？）
- 骨欠損の再生医療用足場材（スキャフォールド）
- ドラッグデリバリー機能付き創傷・骨材料
- 生体適合ゲルの材料設計（非毒性プロセス）
論文3：Substituent Size and Interaction Type Shape Sulfonylurea-β-Cyclodextrin Binding Modes
- 著者：Valencia-Ortega, M; Gutierrez-Flores, J; Huerta, EH; Ramos, E; Gomez-Balderas, R
- 掲載誌：JOURNAL OF PHYSICAL CHEMISTRY B（2026）
- キーワード：
- DOI：10.1021/acs.jpcb.5c06056
何の研究？（ひとことで）
βCDが薬（スルホニル尿素系）をどう包み込むかを、分子動力学と量子化学で詳しく解析した研究
ポイント（やさしく）
- 置換基の大きさにより“入る向き”や安定な結合様式が変わることを統計的に整理。
- 弱い相互作用の“ネットワーク”が安定化の主因で、単一の強い水素結合だけでは説明しにくいことを示す。
- 製剤設計（溶解性・安定性の改善）のための、βCDホスト–ゲスト認識の指針になる。
応用イメージ（どこに役立つ？）
- 難溶性医薬の溶解性向上（包接体）
- CDを用いたドラッグデリバリー設計
- 計算化学によるホスト–ゲスト最適化
参考文献
- Demkiv, O; Stasyuk, N; Holdynski, M; Nogala, W; Gonchar, M. Dual-MIP PEDOT/nCuNi-nanocatalyst sensor for simultaneous detection of dopamine and vanillylmandellate. MICROCHEMICAL JOURNAL (2026). DOI: 10.1016/j.microc.2025.116746
- Rahaman, J; Mukherjee, D. Characterization of Eudragit Nanoparticle-Tailored β-Cyclodextrin/Thiolated Sodium Alginate/Polyethyleneglycol Polymer Hybrid as a Potential Bone Tissue Engineering Scaffold. AAPS PHARMSCITECH (2026). DOI: 10.1208/s12249-025-03314-1
- Valencia-Ortega, M; Gutierrez-Flores, J; Huerta, EH; Ramos, E; Gomez-Balderas, R. Substituent Size and Interaction Type Shape Sulfonylurea-β-Cyclodextrin Binding Modes. JOURNAL OF PHYSICAL CHEMISTRY B (2026). DOI: 10.1021/acs.jpcb.5c06056
English (for Website)
About this page
We summarize only the papers listed in βCDP_20260201.txt with plain‑language explanations.
Rule: if the file contains ≥3 papers, we select the top 3 by journal impact factor. This file has 4 records, so we feature the top 3 by IF.
Journal metrics used for selection (examples)
– Microchemical Journal: JIF 5.1
– AAPS PharmSciTech: JIF 4.0
– The Journal of Physical Chemistry B: 2‑Year Impact Factor 2.9
Paper 1 : Dual-MIP PEDOT/nCuNi-nanocatalyst sensor for simultaneous detection of dopamine and vanillylmandellate
- Authors: Demkiv, O; Stasyuk, N; Holdynski, M; Nogala, W; Gonchar, M
- Journal: MICROCHEMICAL JOURNAL (2026)
- Keywords: Molecularly imprinted polymer; Dual-template sensor; CuNi nanoparticles; Dopamine; Vanillylmandelic acid; Electrochemical detection
- DOI: 10.1016/j.microc.2025.116746
One‑sentence summary
A βCD‑assisted dual molecularly imprinted electrochemical sensor enabling simultaneous, ultra‑sensitive detection of two biomarkers in urine
Key points
- βCD provides host–guest inclusion to enhance selective capture of target analytes within the recognition layer.
- CuNi nanoparticles amplify electrochemical signals to push detection limits to very low concentrations.
- Validation with real urine samples shows strong agreement with HPLC, supporting point‑of‑care potential.
Possible applications
- Point‑of‑care diagnostics and screening
- Compact multi‑analyte sensing platforms
- Design of βCD‑based selective recognition layers
Paper 2: Characterization of Eudragit Nanoparticle-Tailored β-Cyclodextrin/Thiolated Sodium Alginate/Polyethyleneglycol Polymer Hybrid as a Potential Bone Tissue Engineering Scaffold
- Authors: Rahaman, J; Mukherjee, D
- Journal: AAPS PHARMSCITECH (2026)
- Keywords: bone tissue regeneration; eudragit nanoparticle; freeze-thaw; polymer hybrid scaffold; thiolated sodium alginate
- DOI: 10.1208/s12249-025-03314-1
One‑sentence summary
A βCD/thiolated alginate/PEG hybrid hydrogel scaffold, tailored with nanoparticles, for potential bone tissue engineering
Key points
- βCD’s hydrophobic cavity/hydrophilic exterior can strengthen intermolecular interactions and improve loading of functional components.
- A freeze–thaw process forms a hydrogel without harsh chemical crosslinkers while tuning porosity and hydration.
- In vitro biocompatibility and docking analyses suggest relevance for bone regeneration applications.
Possible applications
- Scaffolds for bone regeneration
- Drug‑releasing wound/bone materials
- Biocompatible hydrogel processing routes
Paper 3 : Substituent Size and Interaction Type Shape Sulfonylurea-β-Cyclodextrin Binding Modes
- Authors: Valencia-Ortega, M; Gutierrez-Flores, J; Huerta, EH; Ramos, E; Gomez-Balderas, R
- Journal: JOURNAL OF PHYSICAL CHEMISTRY B (2026)
- Keywords:
- DOI: 10.1021/acs.jpcb.5c06056
One‑sentence summary
Computational insight into how βCD hosts sulfonylurea drugs: substituent size and weak‑interaction networks govern binding modes
Key points
- Molecular dynamics and quantum chemistry identify dominant binding conformations and their populations.
- Stabilization is driven by distributed weak interactions rather than a single strong directional hydrogen bond.
- The results guide βCD‑based formulation strategies to improve solubility and stability of poorly soluble drugs.
Possible applications
- Cyclodextrin inclusion complexes for solubility enhancement
- Rational drug‑carrier design
- Host–guest optimization using computation
References (featured in this page)
- Demkiv, O; Stasyuk, N; Holdynski, M; Nogala, W; Gonchar, M. Dual-MIP PEDOT/nCuNi-nanocatalyst sensor for simultaneous detection of dopamine and vanillylmandellate. MICROCHEMICAL JOURNAL (2026). DOI: 10.1016/j.microc.2025.116746
- Rahaman, J; Mukherjee, D. Characterization of Eudragit Nanoparticle-Tailored β-Cyclodextrin/Thiolated Sodium Alginate/Polyethyleneglycol Polymer Hybrid as a Potential Bone Tissue Engineering Scaffold. AAPS PHARMSCITECH (2026). DOI: 10.1208/s12249-025-03314-1
- Valencia-Ortega, M; Gutierrez-Flores, J; Huerta, EH; Ramos, E; Gomez-Balderas, R. Substituent Size and Interaction Type Shape Sulfonylurea-β-Cyclodextrin Binding Modes. JOURNAL OF PHYSICAL CHEMISTRY B (2026). DOI: 10.1021/acs.jpcb.5c06056
