作成日: 2026-02-07
日本語版（HP向け）
どんなテーマ？
HPβCD（2-ヒドロキシプロピル-β-シクロデキストリン）は、シクロデキストリンの空洞（分子を包み込む部位）を保ちながら、水への溶けやすさを高めた誘導体です。疎水性分子を包接して “水に分散しやすくする” ことで、医薬・食品分析・農薬デリバリーなど幅広い分野で活躍します。
1. Sugar-Armored Pesticides: Self-Assembled System for Enhanced Foliar Adhesion and Sustained Delivery of Hydrophobic Antimicrobials Against Bacterial Diseases
- 掲載誌: ADVANCED SCIENCE（JIF 2024: 14.1）
- 年: 2026
- 著者: Yang, JH; Liu, J; Wang, XH; Wang, PY
- DOI: 10.1002/advs.202524286
やさしい解説（Abstractの要点を整理：本文の転載なし）
– 疎水性（＝水に溶けにくい）農薬は葉の上で弾かれやすく、十分に付着しないため、効果低下や環境流出が起こりやすいという課題がある。
– 本研究は、強力なピリジルエーテル系殺菌剤（PyE28）を HPβCD（2‑ヒドロキシプロピル‑β‑シクロデキストリン） と包接させ、糖で“コーティング”された自己集合体（球状）に変換する戦略を提案。
– 葉面での濡れ広がりが改善し、接触角が小さくなることで付着性が向上（葉への堆積が増える）。
– バイオフィルム形成を強く抑え、植物病原細菌（Xanthomonas）の増殖を抑制することを示した。
– 柑橘かいよう病・イネ白葉枯病の実植物試験でも、従来薬剤より高い防除効果を示し、疎水性農薬の“賢いデリバリー”として有望。
2. Development of portable and highly sensitive electrochemical sensor for rapid on-site analysis of levofloxacin residue in pork samples
- 掲載誌: FOOD CHEMISTRY（JIF 2024: 9.8）
- 年: 2026
- 著者: Cui, X; Chen, XQ; Xiao, TX; Wei, XR; Gong, M; Nan, GJ; Li, YZ; Luo, ZM; Zeng, AG
- DOI: 10.1016/j.foodchem.2026.148010
やさしい解説（Abstractの要点を整理：本文の転載なし）
– 家畜由来食品に残る抗菌薬（レボフロキサシン）の残留は健康リスクとなるため、現場で素早く測れる検査法が求められている。
– 本研究は、電極表面に HPβCDを電気化学重合して固定化し、レボフロキサシンを“包接＋水素結合”で選択的に捕まえるセンサーを設計。
– 検出限界はng/mLオーダーまで低く、幅広い濃度範囲で直線性を示し、共存成分の影響（マトリクス耐性）も小さいと報告。
– 小型の計測器とスマホを組み合わせた携帯型プラットフォームを構築し、豚肉試料のオンサイト測定を実証。
– 食品安全の現場で、迅速・高感度・持ち運び可能な残留抗菌薬検査につながる。
3. Textural Properties of Carbopol® Gel with Curcumin and Curcumin-HPβCD Inclusion Complex and Biological Activities
- 掲載誌: GELS（JIF 2024: 5.3）
- 年: 2026
- 著者: Urosevic, M; Nikolic, V; Savic, V; Mihajilov-Krstev, T; Gajic, I; Dinic, A; Martinovic, M; Nikolic, L
- DOI: 10.3390/gels12010077
やさしい解説（Abstractの要点を整理：本文の転載なし）
– クルクミンは有用な機能性分子ですが、水に溶けにくく、製剤化では溶解性・安定性の改善が課題。
– 本研究は、クルクミンを HPβCD包接体 にしてからCarbopol®ゲルに分散させ、ゲルの物性（テクスチャー・レオロジー）と生物活性を評価。
– DPPH/ABTS/FRAPなどの指標で、包接体の方が抗酸化能が高い傾向を示し、抗菌活性も改善した。
– SEM観察でゲル中にクルクミン/包接体が存在することを確認し、ゲルの構造（粘弾性）は大きく損なわれないことを示した。
– 放出挙動や膨潤性も併せて評価し、外用製剤（塗布剤）としての実用可能性を示唆。
English version (for website)
What is this topic about?
HPβCD (2‑hydroxypropyl‑β‑cyclodextrin) is a water‑soluble cyclodextrin derivative that retains a hydrophobic cavity for host–guest inclusion.
By encapsulating hydrophobic molecules and improving their dispersion in water, HPβCD enables applications ranging from pharma to food analysis and agrochemical delivery.
Selected papers (Top 3 by 2024 JIF)
1. Sugar-Armored Pesticides: Self-Assembled System for Enhanced Foliar Adhesion and Sustained Delivery of Hydrophobic Antimicrobials Against Bacterial Diseases
- Journal: ADVANCED SCIENCE (2024 JIF: 14.1)
- Year: 2026
- Authors: Yang, JH; Liu, J; Wang, XH; Wang, PY
- DOI: 10.1002/advs.202524286
Plain-language bullets (paraphrased from the abstract; no verbatim text)
– Hydrophobic pesticides often show poor deposition on leaves, leading to reduced efficacy and off‑target environmental loss.
– This work complexes a pyridyl‑ether microbicide (PyE28) with HPβCD (2‑hydroxypropyl‑β‑cyclodextrin) to form sugar‑armored, self‑assembled spherical structures in water.
– Improved wetting/spreading on foliar surfaces (lower contact angle) enhances deposition and adhesion.
– The formulation strongly disrupts bacterial biofilms and suppresses Xanthomonas pathogens through oxidative/redox‑related mechanisms.
– In planta tests show improved control of citrus canker and rice bacterial blight versus conventional bactericides, highlighting supramolecular delivery for agrochemicals.
2. Development of portable and highly sensitive electrochemical sensor for rapid on-site analysis of levofloxacin residue in pork samples
- Journal: FOOD CHEMISTRY (2024 JIF: 9.8)
- Year: 2026
- Authors: Cui, X; Chen, XQ; Xiao, TX; Wei, XR; Gong, M; Nan, GJ; Li, YZ; Luo, ZM; Zeng, AG
- DOI: 10.1016/j.foodchem.2026.148010
Plain-language bullets (paraphrased from the abstract; no verbatim text)
– Antibiotic residues such as levofloxacin in animal‑derived foods pose health risks, motivating rapid on‑site testing.
– The sensor electropolymerizes HPβCD on electrodes, leveraging inclusion binding and hydrogen bonding for selective recognition.
– Reports very low detection limits (ng/mL level), wide linear range, strong selectivity, and good matrix resistance.
– Builds a portable platform combining a small workstation and smartphone for on‑site analysis of pork samples.
– Provides a practical route to rapid, sensitive residue monitoring for food safety applications.
3. Textural Properties of Carbopol® Gel with Curcumin and Curcumin-HPβCD Inclusion Complex and Biological Activities
- Journal: GELS (2024 JIF: 5.3)
- Year: 2026
- Authors: Urosevic, M; Nikolic, V; Savic, V; Mihajilov-Krstev, T; Gajic, I; Dinic, A; Martinovic, M; Nikolic, L
- DOI: 10.3390/gels12010077
Plain-language bullets (paraphrased from the abstract; no verbatim text)
– Curcumin is bioactive but poorly water‑soluble, making formulation and stability challenging.
– This study prepares a curcumin–HPβCD inclusion complex and disperses it into Carbopol® gel, then evaluates gel texture/rheology and bioactivity.
– Antioxidant metrics (DPPH/ABTS/FRAP) indicate stronger activity for the inclusion complex, with improved antimicrobial effects as well.
– SEM confirms the presence of curcumin/complex in the gel, while rheology suggests the gel’s structural integrity is preserved.
– Release and swelling tests support feasibility for topical gel formulations.
参考文献 / References（ファイル内・選定3本）
- Yang, JH; Liu, J; Wang, XH; Wang, PY (2026). Sugar-Armored Pesticides: Self-Assembled System for Enhanced Foliar Adhesion and Sustained Delivery of Hydrophobic Antimicrobials Against Bacterial Diseases. ADVANCED SCIENCE. doi:10.1002/advs.202524286
- Cui, X; Chen, XQ; Xiao, TX; Wei, XR; Gong, M; Nan, GJ; Li, YZ; Luo, ZM; Zeng, AG (2026). Development of portable and highly sensitive electrochemical sensor for rapid on-site analysis of levofloxacin residue in pork samples. FOOD CHEMISTRY 504 148010. doi:10.1016/j.foodchem.2026.148010
- Urosevic, M; Nikolic, V; Savic, V; Mihajilov-Krstev, T; Gajic, I; Dinic, A; Martinovic, M; Nikolic, L (2026). Textural Properties of Carbopol® Gel with Curcumin and Curcumin-HPβCD Inclusion Complex and Biological Activities. GELS 12(1) 77. doi:10.3390/gels12010077
Impact Factor (2024) sources (for transparency)
- Advanced Science: Wiley journal metrics page (JIF 14.1).
- Food Chemistry: WoS Journal Info page (JIF 9.8).
- Gels: MDPI journal page / WoS Journal Info (JIF 5.3).
