Cyclodextrin-based Polymers / Materials

by 原 | Posted on

作成日: 2026-02-01

どんなテーマ？

シクロデキストリン（CD）は、分子を“包み込む”性質（包接）をもつ糖由来の材料です。
CDを高分子化（CDポリマー）したり、多孔性材料（CD-MOF）やゲルに組み込むと、

  • 薬をゆっくり放出する（ドラッグデリバリー）
  • 目的の分子だけを選んで測る（センサー）
  • 傷の環境を光で見える化する（スマート材料）

といった機能が作れます。

選定論文

Dynamic Slide-Ring Hydrogels with Dityrosine-Driven pH-Responsive Fluorescence: Enabling 3D Printing, Enhanced Drug Delivery and Regenerative Therapy

  • 掲載誌: ADVANCED HEALTHCARE MATERIALS
  • 年: 2026
  • 著者: Li, Y; Xu, MY; Li, HK; Ni, FJ; Xiao, H; Shen, HY; Zeng, SY; Ma, YH; Zhang, L
  • DOI: 10.1002/adhm.202503936

やさしい解説
– α-シクロデキストリン（α-CD）をベースにした“スライドリング”型の超分子ハイドロゲルを設計。
– 押し出し式3Dプリントができる“流れる→止まる”性質（せん断薄化）と、すぐ元に戻る自己修復性を両立。
– pHで光り方が変わる蛍光ユニットを組み込み、創傷環境などの変化を“見える化”できる。
– 抗菌薬（トブラマイシン）を担持して徐放し、感染創モデルで治癒促進や炎症制御に寄与した。

Dual-MIP PEDOT/nCuNi-nanocatalyst sensor for simultaneous detection of dopamine and vanillylmandellate

  • 掲載誌: MICROCHEMICAL JOURNAL
  • 年: 2026
  • 著者: Demkiv, O; Stasyuk, N; Holdynski, M; Nogala, W; Gonchar, M
  • DOI: 10.1016/j.microc.2025.116746

やさしい解説
– β-シクロデキストリンと導電性高分子（PEDOT）を使い、分子鋳型（MIP）で“目的分子だけ”を選びやすい電気化学センサーを作製。
– ドーパミン（DA）とVMAを同時に測る“二重テンプレート”設計で、2種類のバイオマーカーを一度に解析。
– Cu-Niナノ粒子で電気信号を増強し、低濃度（nMレベル）でも検出できる感度を実現。
– ヒト尿サンプルで実証し、HPLC結果とよく一致（ポイントオブケア診断への展開が期待）。

Exploring Cyclodextrin-Based MOFs for Drug Delivery: Synthesis, Applications, and Future Perspectives

やさしい解説
– シクロデキストリン（CD）を“有機リンカー”として組み込んだCD-MOF（多孔性材料）を概説したレビュー。
– 従来MOFより“生体適合性”を重視でき、薬物担体としての安全性設計に利点がある。
– 合成法のバリエーション、薬物の取り込み（ロード）方法、各方法の長所・注意点を整理。
– ドラッグデリバリーでの応用可能性を俯瞰し、今後の材料設計の指針を提供。

English version (for website)

What is this topic about?

Cyclodextrins (CDs) are sugar-derived molecules that can “host” other molecules in their cavity (inclusion/encapsulation).
By converting CDs into polymers, porous frameworks (CD-MOFs), or hydrogels, researchers can create materials that:

  • release drugs in a controlled way,
  • selectively detect target molecules (sensors),
  • and even visualize environmental changes (responsive fluorescence).

How the 3 papers were selected

Since the attached file contains more than three papers, we selected the top 3 by Journal Impact Factor (JIF 2024) of the publishing journal (highest first).

Selected papers

Dynamic Slide-Ring Hydrogels with Dityrosine-Driven pH-Responsive Fluorescence: Enabling 3D Printing, Enhanced Drug Delivery and Regenerative Therapy

  • Journal: ADVANCED HEALTHCARE MATERIALS (JIF 2024: 9.6)
  • Year: 2026
  • Authors: Li, Y; Xu, MY; Li, HK; Ni, FJ; Xiao, H; Shen, HY; Zeng, SY; Ma, YH; Zhang, L
  • DOI: 10.1002/adhm.202503936

Plain-language bullets (paraphrased from the abstract)
– Design of an α-cyclodextrin–based supramolecular “slide-ring” hydrogel.
– Combines shear-thinning (printable by extrusion) with rapid self-healing to keep printed shapes stable.
– Built-in pH-responsive fluorescence enables real-time monitoring of the local microenvironment.
– Loads and releases an antibiotic (tobramycin) in a sustained manner, improving outcomes in an infected wound model.

Dual-MIP PEDOT/nCuNi-nanocatalyst sensor for simultaneous detection of dopamine and vanillylmandellate

  • Journal: MICROCHEMICAL JOURNAL (JIF 2024: 5.1)
  • Year: 2026
  • Authors: Demkiv, O; Stasyuk, N; Holdynski, M; Nogala, W; Gonchar, M
  • DOI: 10.1016/j.microc.2025.116746

Plain-language bullets (paraphrased from the abstract)
– An electrochemical sensor combining β-cyclodextrin and a conductive polymer (PEDOT) with molecular imprinting for selectivity.
– Dual-template imprinting enables simultaneous measurement of dopamine (DA) and vanillylmandelic acid (VMA).
– Cu–Ni nanoparticles amplify electrochemical signals, reaching nanomolar-level detection limits.
– Validated in human urine samples with good agreement to HPLC, suggesting potential for point-of-care testing.

Exploring Cyclodextrin-Based MOFs for Drug Delivery: Synthesis, Applications, and Future Perspectives

Plain-language bullets (paraphrased from the abstract)
– A review of cyclodextrin-based metal–organic frameworks (CD-MOFs) as porous materials.
– Highlights biocompatibility advantages compared with many conventional MOFs, important for drug carriers.
– Summarizes synthesis routes and drug-loading strategies, including practical pros/cons.
– Provides a roadmap for designing CD-MOFs for drug-delivery applications.

参考文献 / References

  • Li, Y; Xu, MY; Li, HK; Ni, FJ; Xiao, H; Shen, HY; Zeng, SY; Ma, YH; Zhang, L (2026). Dynamic Slide-Ring Hydrogels with Dityrosine-Driven pH-Responsive Fluorescence: Enabling 3D Printing, Enhanced Drug Delivery and Regenerative Therapy. ADVANCED HEALTHCARE MATERIALS. doi:10.1002/adhm.202503936
  • Demkiv, O; Stasyuk, N; Holdynski, M; Nogala, W; Gonchar, M (2026). Dual-MIP PEDOT/nCuNi-nanocatalyst sensor for simultaneous detection of dopamine and vanillylmandellate. MICROCHEMICAL JOURNAL. doi:10.1016/j.microc.2025.116746
  • Edisan, S; Mutlu-Agardan, NB (2026). Exploring Cyclodextrin-Based MOFs for Drug Delivery: Synthesis, Applications, and Future Perspectives. ACS OMEGA. doi:10.1021/acsomega.5c10791

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